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Involvement of fibroblast growth factor 2 (FGF2) and its receptors in the regulation of mouse sperm physiology
(BioScientifica, 2018-08)
Fibroblast growth factor 2 (FGF2) and its receptors (FGFRs) have been described in several tissues, where they regulate cellular proliferation, differentiation, motility and apoptosis. Although FGF2/FGFRs expression in the ...
Interaction between FGFR-2, STAT5, and progesterone receptors in breast cancer
(American Association for Cancer Research, 2011-05)
Fibroblast growth factor (FGF) receptor 2 (FGFR-2) polymorphisms have been associated with an increase in estrogen receptor and progesterone receptor (PR)-positive breast cancer risk; however, a clear mechanistic association ...
A Sensory Neuron Subpopulation with Unique Sequential Survival Dependence on Nerve Growth Factor and Basic Fibroblast Growth Factor during Development
(Society for Neuroscience, 2001-11)
We characterized a subpopulation of dorsal root ganglion (DRG) sensory neurons that were previously identified as preferential targets of enkephalins. This group, termed P-neurons after their “pear” shape, sequentially ...
Follicular wave dynamics and Growth factors gene expression in Braford heifers
(Wiley Blackwell Publishing, Inc, 2020-11)
The objectives of the present study were (experiment 1) to characterized development and dynamics of the dominant follicles (DF) and the corpus luteum (CL) to determine patterns of two (W2) and three (W3) follicular waves ...
Deficiency of fibroblast growth factor 2 (FGF-2) leads to abnormal spermatogenesis and altered sperm physiology
(Wiley-liss, Div John Wiley & Sons Inc, 2018-12)
In previous studies, we described the presence of fibroblast growth factor 2 (FGF-2) and its receptors (FGFRs) in human testis and sperm, which are involved in spermatogenesis and in motility regulation. The aim of the ...
Fibroblast deficiency of insulin-like growth factor 1 receptor type 1 (IGF1R) impairs initial steps of murine pheochromocytoma development
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2019-08)
Insulin-like growth factor 1 (IGF1) has a critical role in maintaining tumor phenotype and survival of already transformed murine pheochromocytoma (pheo) cells (MPC4/30) and it is required for the initial establishment of ...
Interleukin 1 beta and matrix metallopeptidase 3 contribute to development of epidermal growth factor receptor–dependent serrated polyps in mouse cecum
(W B Saunders Co-Elsevier Inc, 2019-12)
Background & Aims: Transgenic mice (HBUS) that express the epidermal growth factor receptor (EGFR) ligand HBEGF (heparin-binding epidermal growth factor–like growth factor) and a constitutively active G protein–coupled ...
Fibroblast growth factor-2 expression during experimental oral carcinogenesis. Its possible role in the induction of premalignant fibrosis
(Wiley Blackwell Publishing, Inc, 2006-12)
BACKGROUND: The fibroblastic growth factor (FGF)-2 has been shown to induce angiogenesis in several tumor types. To date, the activity of FGF during the development of oral pre-cancerous lesions has not been analyzed. We ...
Fibroblast growth factor-2 in hyperplastic pituitaries of D2R knockout female mice
(American Physiological Society, 2007-11)
Dopamine D2 receptor (D2R) knockout (KO) female mice develop chronic hyperprolactinemia and pituitary hyperplasia. Our objective was to study the expression of the mitogen fibroblast growth factor (FGF2) and its receptor, ...
Nuclear action of FGF members in endocrine-related tissues and cancer: interplay with steroid receptor pathways
(Elsevier Science Inc, 2019-09)
Dysregulation of the fibroblast growth factors/fibroblast growth factor receptor (FGF/FGFR) pathway has been implicated in a wide range of human disorders and several members have been localized in the nuclear compartment. ...